Lowering body weight in people with obesity has clear benefits in preventing, delaying or making the management of obesity-related co-morbidities (type 2 diabetes, cardiovascular disease) more effective.

Lowering blood glucose levels in people with type 2 diabetes has clear benefits for preventing microvascular complications and potential benefits for reducing macrovascular complications and death.

Treatment needs to be individualised for the person with obesity and diabetes. This should start with selection of the appropriate weight and glucose targets, taking into account life expectancy, and the wishes of the person with obesity and diabetes. For most people, early use of therapies is warranted. A range of recently available therapies have added to our range of options for lowering body weight and glucose, but this has made the clinical pathway more complicated.

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